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Research History of Miyauchi Citrus Research Center, Ltd.
 
"Let food be thy medicine,
and medicine be thy food"
 
   
1978
Observing the change of freshly squeezed watermelon juice for a period of time triggered Miyauchi’s interest to study stopping its change in natural environment.



1982 Among thousands of different species of plant extracts, Miyauchi tried to extract on her own methods and found the most stable extract—Citrus Peel Extract. Furthermore, the mix of certain citrus peel extracts along with the formula which does not require any preservatives for over two years and more in room temperature were found. Consulted the late former First Lady, Mrs. Ikeda (Prime Minister Hayato Ikeda), and was persuaded to establish a company to market citrus-peel-extract product.  Mrs. Ikeda named the product “GOLD.”  Today we refer the product as "Gold Lotion" or "GL." Mrs. Ikeda assisted Miyauchi for required paperwork to obtain a permit to produce and sell to the Ministry of Health, Labor and Welfare.
Four species of extracts were found to be never introduced in the world market; the Ministry of Health, Labor and Welfare suggested to send raw materials of each extract to Huntingdon Research Center in England for the safety studies.



1983 Huntingdon Research Center accepted the studies.



1984 The Tokyo Metropolitan Institute of Public Health interested in our product, studied, and found the major compound for anti-fungi -- nootkatone; further tested for anti-fungi.  Recommended as a use of prevention of hospital-acquired infection since extract inhibit proliferation of Pseudomonas aeruginosa.



1985

Reapplied for the permit* and accepted as the very First Natural Cosmetics – the New Product.

*Permits:  In Japan there are three categories:
1) pharmaceuticals, 2) non-medicated pharmaceuticals, and 3) cosmetics. 
Our product was given #2 permit.  Documentations for #2 permits are required to be audited every 5 years.




Named by former First Lady Mitsue Ikeda
Original Gold Lotion (120mL, 55mL)
Yutaka Miyauchi at the opening party

at late former Prime Minister Hayato Ikeda's Home
Miyauchi & Mrs.Ikeda   
 

1986

1987
Started producing and selling CPE/OPE (orange peel extract) product “GOLD.”  Made the studies public at the 51st Food Science Society recommending as natural preservative. 



1989 Miyauchi was awarded an invention patent of 20 years including production methods, usages, and compounds in Japan.



1990 Per Miyauchi’s request, to supply the perfect extract product, distributions of products were limited: 1) individual beauty shops and 2) direct distribution to the individuals by mail-order system.  Beauty shops’ owners started to use CPE/OPE product for keeping up with healthy scalps and claimed that their clients’ hairs growing faster and longer.

Started random tests of volunteers to confirm their claims. Requested the in vivo studies using rabbit’s papilla cells at Kitasato University Research Institute and Japan Hair Science Association.




1995 Continued study as a hair grower of CPE/OPE found and substance purified—peptide including 23 amino acids.  We found the exact stimulating substance for hair growth, but no public announcement to this day—confidential matter.
Japan Cosmetics Society refused our presentation; therefore, we applied to Japan Pharmaceutical Society to present our study results, and accepted.




1996

At the 116th Japan Pharmaceutical Society scientists made a presentation—Media release.
Miyauchi holds patents by USA, England, France, Germany for 20 years.




 

2001

Started receiving claims by customers of various diseases – gastric ulcer, lentigines, hypertension, etc.
Started random human trials with volunteers including dogs (house pets per owners’ requests).



2002 Consulted scientists and medical doctors for trials; could not come to the agreement of terms of contract.
Professor and medical doctor, Dr. Okamura agreed to assist us with his patients.




2003 Successfully produced soils from industrial waste of orange peel and residual extract mixing with other plants’ extract to produce “the safest vegetables and fruits.”  Established the company called Miyauchi Citrus Fermentation.  The whole purpose of establishing this company was to TEACH not only the producers but also the consumers “ the possible production of agricultural produce without any chemicals” and “the importance of FOOD products’ SAFETY.”



2004 Requested Kitasato University Research Institute and Iwaki Meisei University to test our product for possibility of anticancer agent.



2005 Inhibiting proliferation of KB/VJ300 with vincristine. Result indicated the enhancement of vincristine over 80 times and more in 5 days.



2008 Their study resulted in presentation at the 128th Japan Pharmaceutical Society – Anti-Inflammatory Effects of our product – inhibiting the production of NO, TNF-α
At this presentation, regrettably could not identify the effective major compounds.




2009 Dr. Shiming Li of WellGen, Inc., studied our product and identified and quantified the compounds.  Signed the contract for further study.



2010/
8/22
Signed the contract for in vivo studies.
Poster presentation at ACS in Boston on August 22.



2010/
12/17
Oral presentation for anticancer at PacifiChem, sponsored by ACS in Hawaii in December by Dr. Shiming Li, Dr. Nancy Rawson.



2011/
Aug
.

Applied PCT for a carcinostatic of prostate cancer



2012/
Feb.
Applied patent for prostate canser treatment for U.S.A. and Taiwan



2012/
5/18
Oral presentation at World Congress Conference (World Cancer Congress 2012) in Beijing, China.
"Efficient treatment of prostate cancer with phytochemicals from citrus genus"




 2012/
5/20
 Oral presentation at World Congress Conference (World Cancer Congress 2012) in Beijing, China.
"In vivo anti-tumor activity of polymethoxyflavones from citrus peels"




 2012/
Dec.
Paper "Molecular Nutritrion and Food Research" published:
Effective suppression of azoxymethane-induced aberrant crypt foci formation in mice with citrus
peel flavonoids
Paper "Food Science and Human Wellness" published:
Inhibition of citrus flavonoids on 12-O-tetradecanoylphorbol 13-acetate-induced skin
inflammation and tumorigenesis in mice
Paper "Food & Function"
Potent anti-cancer effect of citrus peel flavonoids in human prostate xenograft tumors



2013/
3/8
 
"Notice of Allowance" received for US patent
Applied patents for Europe and Canada for "Prostate cancer treatment"



2013/
5/11-12
The 13th International Conference -- Functional and Medical Foods (see the content - link)
 See the part of presentation content -- click here  See the abstract -- click here



2013/
8/20-22
14th International Conference at UCLA –
Functional Foods and Bioactive Compounds in the Management of Chronic Inflammation: Science and Practical Application
Received “Presentation Award” (see the content – link). At this presentation a part of on-going studies for CL1-5, by Dr. Lin of National Chung Hsing University, Taiwan, also was introduced by Dr. Shiming Li of Rutgers University, New Jersey, USA (see the abstract – click here)



2013/
8/23
US patent “US8,425,952 B2”  (Registered on Aug. 20, 2011)
Granted METHOD FOR TREATING PROSTATE CANCER



2013/
11/5-9
2013 International Conference & Exhibition on Nutraceuticals and Functional Foods
in Taipei, Taiwan
Formulated extract from multiple citrus peels impairs immune dendritic cells functions and attenuates allergic contact hypersentivity
At this time, we ended up with Poster presentation; however, it was well received!
For "Abstract, Cooporated Researchers & Universities, References" (click here/)



2014/
5/10-11
15th International Conference at University of Regensburg, Regensburg, Germany
We presented 2 oral and poster presentations.
1) Formulated extract from multiple citrus peels impairs dendritic cell functions and attenuates allergic contact hypersensitivity by Dr. Shiming Li, USA (click here for the abstract)
2) Potent anti-Imiquimod-induced psoriasis of formulated citrus peel extract in mice by Dr. Chi-Chen Lin, Taiwan (click here for the abstract)
The both presentations were made by Dr. Shiming Li because of Dr. Lin’s schedule conflict. Dr. Lin’s in vivo studies were praised and drew so much attention and many interests at the conference. Wished he was with us to enjoy a massive applause from the audience.



2014/
July 26-27
Oral Presentations by Dr. Chi-Chen Lin of findings at 16thInternational Conference of FFC in Chengdu, Sichuan, China: Functional Foods, Bioactive Compounds and Biomarkers: Research and Practical Application Presentations by Dr. Shiming Li of USA and Dr. Chi-Chen Lin of Institute of Biomedical Sciences and National Chung Hsing University, Taiwan.
Note: Dr. Lin’s students received the research award presented at local conference in Taiwan.
(Click here)



2014/
Oct.14-17
Oral Presentation by Dr. Manashi Bagchi of Dr HEREBS LLC, Chief Research Officer in Istanbul, Turkey, at 2014 Annual Conference & Exhibition by Functional Foods, Nutraceuticals,
Natural Health Products, and Dietary Supplements. Refer to Book of Abstract – www.isnff2014.org.
Introduced the partial in vivo results of A549 and CL1-5 provided by Dr. Chi-Chen Lin of Institute of Biomedical Sciences and National Chung Hsing University, Taiwan(Click here)



2014/
Oct.17-19

The 64th Japan Urology Association Central General Meeting was held in Hamamatsu City, Shizuoka. Two Oral Presentations were performed by Dr. Kageyama of Kageyama Clinic (urology) and Dr.Ohmura of Ohmura Clinic (urology). Click here for the content of presentations cooperated by Dr. Hayami of Fujieda City Hospital, Director of Urology Dept.; Dr. Yamada of Shizuoka University,
Center for Pharma-Food Research.
At this conference we were invited to set up the booth at the 103rd Japan Urology Association General Meeting to be held during next April 18th through 21st in Kanazawa, Japan. The number of attendees is expected to be 5500 MDs



2014/
Nov.5-6

The 2nd International Conference on Pharma and Food was held in Nihondaira, Shizuoka City, Japan. One Oral Presentation on GL’s in vivo results including Lung cancers using A549 and CL1-5
by Dr.Chi-Chen Lin of National Chung Hsing University, Taiwan. Click here for his abstract on GL. Another Oral Presentation
introduced by Dr. Shiming Li, Rutgers University, USA; Professor,Huanggang Normal Uiversity, China. Click here for his abstract on GL’s compounds analyses.



2015/
Apl.18-21


We are requested to attend and set up the booth to introduce Gold Lotion, GL, (citrus peel extract) at the 103rd Japan Urology Association General Meetings to be held in Kanazawa, Ishikawa. Expected attendees of MDs are now 5500 or more.
2015/
Jun.12
Japan "5760098" PROSTATE CANCER TREATING MEDICATION



2015/
Jun
Canada METHOD FOR TREATING PROSTATE CANCER



2015/
Aug.19
 
Taiwan "10421103200" METHOD FOR TREATING PROSTATE CANCER


2016/
Apl.23-25

The 104th Japanese Urological Association (JUA)
The follow-up presentation on prostate cancer Active Surveillance patient after a year and a half later taking GL, citrus-peel extract mix, was performed by Dr. Shinji Kageyama of Kageyama Clinic specializes Urology.

Supported by:
Director of Urology Dept., Chief Surgeon of Fujieda City Hospital
 Dr. Shinsuke Hayami, Ph.D. Medical Science
Director and Owner of Ohmura Clinic, Urology
 Dr. Seiji Ohmura
Director of Shizuoka Prefectural University, Pharma and Food Center
 Dr. Shizuo Yamada, Ph.D. Pharmacology, etc.




2017/
May 30
by Viligelmo Veterinary Clinic, Modena, Italy Department of Medical, Oral and Biotechnol
ogical Sciences, Dental School, University G. D Annunzio of Chieti-Pescara, Chieti, Italy
Dr. Paolo Giazzi, Dr. Alessandro Di Cerbo Research study accepted by J Vet Med Alled Sci 2017 Volume 1 Issue 1
Title “Effectiveness of a formulated produce (Gold Lotion) in improving the quality of life (QoL) of oncological cats: preliminary results.
Gold Lotion as adjuvant of current pharmacological therapy in 18 cats affected by different tumors (digestive system lymphoma, carcinoma and cutaneous fibrosarcoma).
http://www.alliedacademies.org/veterinary-medicine-and-allied-science/