|２０１０||Presentation at American Chemical Society (ACS)
Conference in Boston, New Jersey USA
De-convolution of medicinal citrus products
Shiming Li1, Yutaka Miyauchi2, Michiko Suzawa2, Terry Nash2, Nancy E. Rawson1, Chi-Tang Ho3
1) WellGen, Inc., North Brunswick, NJ USA
2) Miyauchi Citrus Research Center, Ltd., 610 Iwai, Yoshii-machi, Takasaki, Gunma, Japan
3) Department of Food Science, Rutgers University, New Brunswick, NJ USA
Introduction of Citrus Products on the market: Gold Lotion, Sytrinol
<Medicinally used products> Sytrinol, KGK Synergizer, Canada
▪ Components disclosed: Polymethoxyflavones (tangeretin, nobiletin, etc), Tocotrienols
▪ Major claims: Recommended dosage 300 mg/day/person, lowering total cholesterol and LDL
cholesterol by up to 27%, compared to placebo, improving triglycerides up to 34%,
compared to placebo.
<Gold Lotion> Biological activities
▪ Anti-inflammation: iNOS, TNFα
▪ Anti-carcinogenic: details follow
▪ Anti-microbial: S. aurenus, S. griseus, P. digitatum, F. oxysporus, T. aentagrophytes, M. gypseum,
P. aeruginosa, V. parahacmolyticus, etc.
▪ Hair growth stimulating agent
▪ Skin whitening
<Biological activity of citrus compounds>
Flavonoids (hesperidin, etc.), PMFs (polymethoxyflavones), OH-PMFs (hydroxylated polymethoxyflavones)
▪ Anti-inflammatory Activity of PMFs and OH-PMFs
▻ Down-regulation of multiple enzymes: COX-2, iNOS, myeloperoxidase,
TNF-α MMP-1, MMP-3, MMP-9, PGE2, etc
▻ Suppression of gene expression: COX-2, iNOS, IL-1a, IL-1b, TNF-α and IL-6, AP-1, NF-kB, etc.
▻ Product inhibition: NO, O2-, PGE2
▪ Anti-carcinogenic Property of PMFs and OH-PMFs
▻ Inhibition of tumor cell proliferation
▻ Inhibition of NO, O2-, PGE2 production and tumor promotion
▻ Induction of apoptosis
▪ OPE (orange-peel extract): Cancer Prevention and Treatment
▻ Inhibition of cellular growth without cell death
Patented by (1)KGK Synergize Inc., 2008; (2)Ho et al, Rutgers
▻ Increased apoptosis in ductal epithelial cells of mouse mammary gland
(Journal of Medi Food, 2007, 10, 11)
▻ Nobiletin against lung cancer induced by cigarette smoking
▻ Synergistic effect in H2O2-induced apoptosis in human neuroblastoma SH-SY5Y cells, produced
by the combination of tangeretin and 5-demethylnobiletin
▪ Anti-atherosclerosis Activity
▪ Apoptotic activity of PMF Metabolites
▪ Other Applications
▻ Anti-fungal agents against Penicillin digitatum
Viticultura Enologia Professional, 2006, 91-99
▻ Anti-Obesity drug from PMFs and OH-PMFs
▪ OH-PMF Bioactivity compared with PMFs
▪ Introduction of PMF Content in Gold Lotion Extract
<PacifiChem 2010, Honolulu, Hawaii, United States, Dec. 15-20, 2010>
Shiming Li, Michiko Suzawa, Terry Nash, Nancy E. Rawson, Chi-Tang Ho.
Health promoting use and composition analysis of commercial citrus peel products.
Abstracts of Papers
<240th ACS National Meeting, Boston, MA, United States, Aug. 22-26, 2010, MEDI-238>
Shiming Li, Michiko Suzawa, Terry Nash, Nancy E. Rawson Chi-Tang Ho.
De-convolution of medicinal citrus products.
Abstracts of Papers